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Note that HCV particles incorporate both viral factors and host-derived lipoproteins. Among these viral factors, two proteins have been key targets for development of directly acting antivirals (DAAs) for treatment of hepatitis C, namely the viral serine protease complex consisting of NS3 and 4A which is responsible for all polyprotein cleavage steps downstream of NS3 and the RNA-dependent RNA polymerase (Rd Rp) NS5B, the catalytic center of HCV genome replication.

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